Neuroscience Paris-Seine – IBPS
UPMC UM CR18 – CNRS UMR 8246 – INSERM U1130
Equipe Neurophysiologie et Comportement (NPC)
Boite 16, Universite P. et M. Curie,
9 quai St Bernard, 75005, Paris, FRANCE
Tel: +33 1 44 27 39 40
samir.takillah at gmail.com
Understanding the neurobiology of schizophrenia by electrophysiological and pharmacological approaches.
Project and research interests
In vivo electrophysiological recording of the neural networks dynamics in the prefrontal cortex, the hippocampus and the ventral tegmental area in mice with a microdeletion in the region of chromosome 16 syntenic to the 22q11.2 microdeletion, which increases the risk of developing schizophrenia.
Spectral analysis of local field potentials (EEG) of both cortex and statistical relationships (Coherence).
I will investigate how the acute antipsychotic treatment improves behavioral deficits by restoring communication between both cortex, but also how the firing rate dynamics of dopaminergic and GABAergic neurons of the ventral tegmental area is modulated by the environment and the expressed behavior.
- Electrodes Manufacturing, surgery
- Signal Processing
- Programming (Matlab)
- Takillah S., Naudé J., Decros B., Didienne S., Sebban C., Mariani J., Schenker E., Spedding M., Faure P. Investigation of hippocampal-frontal cortex circuits in schizophrenia models using electroencephalography in rodent. SFN Meeting, New Orleans (2012).
The research leading to these results were performed in conjunction with the European Community’s Seventh Framework Programme (FP7/2007-2013) for the Innovative Medicine Initiative under Grant Agreement n°115008.