Nicolas Torquet

2015_01_30_photo_equipe_0105-7

Nicolas Torquet
Engineer (IE2) CNRS
Neuroscience Paris-Seine – IBPS
UPMC UM CR18 – CNRS UMR 8246 – INSERM U1130
Equipe Neurophysiologie et Comportement (NPC)
Boite 16, Universite P. et M. Curie,
9 quai St Bernard, 75005, Paris, FRANCE
Tel: +33 1 44 27 39 40
nicolas.torquet at upmc.fr
CV pdf file

General interests

I am taking advantage of my dual expertise in biology and computing to work at the interface between these two domains. In biology, I am interested in the neurobiological mechanisms underlying animal behavior. In parallel, I am developing softwares, mostly databases and their graphical interfaces, to improve reliability and efficiency in data analysis.

Projects

Souris City

2013_06_06_souriscity_0026rSouris City is an innovative project that will allow to explore mouse behaviors in a more complex environment than standard housing conditions. Indeed, Souris City is composed of several compartments connected through “tubes and scales”, resembling the natural living conditions of mice. Other modules will be additionally connected, allowing standardised testing of the animals. The environment is also socially enriched, the group housed together being larger than in standard conditions. Mice are observed 24/7 in the different compartments. Such a setting will allow to gather information on the hierarchical structure within a group and to combine this information with the performances of the animals in the standardised tests conducted in parallel.

mouseTube

logo_mousetube_littlemouseTube is an online database allowing scientists to share mouse ultrasonic vocalization audio files. mouseTube allows to sort vocalization recordings by mouse strain, or by a given context within a protocol. mouseTube facilitates the comparison of ultrasonic vocalizations between individuals, strains, contexts… Link to mouseTube.

Here is a short video introduction to mouseTube:

Databases

Various databases are being built in the lab for storage and easy recollection of electrophysiological or behavioral data.

Publications

  • Tolu S., Marti F., Morel C., Perrier C., Torquet N., Pons S., de Beaurepaire R., Faure P. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific Report [Article].
  • Royet J.-P., Meunier D., Torquet N., Mouly A.-M., Jiang T.
    The Neural Bases of Disgust for Cheese: An fMRI Study
    Front. Hum. Neurosci. 10:511. doi: 10.3389/fnhum.2016.00511 (2016) [Abstract]
  • Torquet N., De Chaumont F., Faure P., Bourgeron T., Ey E.
    mouseTube – a database to collaboratively unravel mouse ultrasonic communication
    F1000Research, 5:2332, doi: 10.12688/f1000research.9439.1 (2016). [Abstract]
  • Ferhat A.-T., Torquet N., Le Sourd A.-M., de Chaumont F., Olivo-Marin J.-C., Faure P., Bourgeron T., Ey E.
    Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication.
    J. Vis. Exp. (112), e53871, doi:10.3791/53871 (2016). [Abstract]
  • Naudé J., Tolu S., Dongelmans M., Torquet N., Valverde S., Rodriguez G., Pons S., Maskos U., Mourot A., Marti F., Faure P.
    Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.
    Nature Neuroscience, january 2016, doi:10.1038/nn.4223. [Abstract]
  • Torquet N., Aimé P., Messaoudi B., Garcia S., Ey E., Gervais R., Julliard A.K., Ravel N. (2014) Olfactory preference conditioning changes the reward value of reinforced and non-reinforced odors. Frontiers in Behavioral Neuroscience. doi: 10.3389/fnbeh.2014.00229. Publication Date (Web): July 3, 2014. [Abstract]
  • Ey E., Torquet N., Le Sourd A.-M., Leblond C. S., Boeckers T. M., Faure P., Bourgeron T. (2013) The Autism ProSAP1/Shank2 mouse model displays quantitative and structural abnormalities in ultrasonic vocalisations. Behav. Brain Res. 2013 Aug 28. [Abstract]
  • Ey E., Yang M., Katz A.M., Woldeyohannes L., Silverman J.L., Leblond C.S., Faure P., Torquet N., Le Sourd A.-M., Bourgeron T., Crawley J.N. (2012) Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4. Genes Brain Behav. 2012 Sep 18. doi: 10.1111/j.160 [Abstract]
  • Schmeisser* M.J., Ey* E., Wegener* S., Bockmann J., Stempel A.V., Kuebler A., Janssen A.L., Udvardi P.T., Shiban E., Spilker C., Balschun D., Skryabin B.V., Dieck St., Smalla K.H., Montag D., Leblond C.S., Faure P., Torquet N., Le Sourd A.-M., Toro R., Grabrucker A.M., Shoichet S.A., Schmitz D., Kreutz M.R., Bourgeron T., Gundelfinger E.D., Boeckers T.M. (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature 486(7402):256-260. doi: 10.1038/nature11015 [Abstract]
  • Alonso M., Lepousez G., Wagner S., Bardy C., Gabellec M.-M., Torquet N., Lledo P.-M. (2012) Activation of adult-born neurons facilitates learning and memory. Nat. Neurosci. 897-904. [Abstract] F1000
  • Lazarini F., Gabellec M.M., Torquet N., Lledo P.-M. (2012) Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb. J. Neurosci. 32(11):3652-3664. [Abstract]
  • Bohn P., Le Fur N., Hagues G., Costentin J., Torquet N., Papamicaël C., Marsais F., Levacher V. (2009) Rational design of central selective acetylcholinesterase inhibitors by means of a “bio-oxidisable prodrug” strategy. Org. Biomol. Chem. 7(12) :2612-2618. [Abstract]
  • Torquet N., Hagues G., Costentin J. (2008) The reduction in electric footshocks perception interferes with the amnesic effect of scopolamine. Behav. Brain. Res. 188(1):238-240. [Abstract]

Softwares

  • mouseTube (Website and database to share mouse vocalisation recordings)
  • electroDream (Database and web interfaces to manage experimental data from electrophysiology experiments)
  • Data Dock (Databases and web interfaces to manage experimental data and stocks of biochemicals)

Previous labs

  • CNRS URA 2182 Genes, Synapses et Cognition – CNRS and Institut Pasteur, Paris
  • Neurobiologie de la mémoire olfactive team, CNRS UMR5020, Lyon
  • CNRS FRE 2735 Neuropsychopharmacologie expérimentale, Rouen