Jérémie Naudé

2014_02_14_labo_jeremie_2330

Jérémie Naudé
Post doctoral position
Neuroscience Paris-Seine – IBPS
UPMC UM CR18 – CNRS UMR 8246 – INSERM U1130
Equipe Neurophysiologie et Comportement (NPC)
Boite 16, Universite P. et M. Curie,
9 quai St Bernard, 75005, Paris, FRANCE
Tel: +33 1 44 27 39 40
jeremie.naude at gmail.com
CV pdf file

Project

I am interested in integrative neurobiology. How can neural processes ranging from fast electrical activity to slow neuromodulation and long-term plasticity give rise to “adapted” behavior? I try to understand the causal relations between different levels of organization (neurons, networks, animal behavior) and timescales. I previously worked with theoreticians to build and analyze models of neural plasticity.
I am currently involved in experimental projects studying how a neuromodulator, dopamine, affects downstream neural networks (and henceforth decision-making) and how dopaminergic neurons are modulated by upstream structures. I use computational modeling to constrain behavioral experiments with mice, using in vivo techniques such as multi-electrode recordings, optogenetics stimulation, knock-out animals and targeted viral reexpression. I also collaborate with neurobiologists to analyze the dynamics of their large-scale neural recordings (EEG and calcium imaging).

Research interests

  • Neuromodulation and decision-making
  • Neurobiology of learning and memory, neuronal plasticity
  • Neural networks dynamics, oscillations and synchrony

Methods

  • Computational modeling
  • Animal conditionning
  • In vivo electrophysiology
  • In vivo optogenetics
  • Viral injections

Main publications

  • Naudé J., Tolu S., Dongelmans M., Torquet N., Valverde S., Rodriguez G., Pons S., Maskos U., Mourot A., Marti F., Faure P.
    Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.
    Nature Neuroscience, january 2016, doi:10.1038/nn.4223. [Abstract]
  • Faure P., Tolu S., Valverde S., Naudé J.
    The role of nicotinic acetylcholine receptors in regulating Dopamine neuron activity.
    Neuroscience, Just Accepted Manuscript. doi: 10.1016/j.neuroscience.2014.05.040. Publication Date (Web): May 29, 2014. [Abstract]
  • Naudé, J., Cessac, B., Berry, H., Delord, B. (2013). Effects of cellular homeostatic intrinsic plasticity on dynamical and computational properties of biological recurrent neural networks. The Journal of Neuroscience, 33(38), 15032-15043.
  • Naudé, J., Paz, J. T., Berry, H., Delord, B. (2012). A theory of rate coding control by intrinsic plasticity effects. PLoS computational biology, 8(1), e1002349.
  • Serreau, P., Chabout, J., Suarez, S. V., Naudé, J., Granon, S. (2011). Beta2-containing neuronal nicotinic receptors as major actors in the flexible choice between conflicting motivations. Behavioural brain research, 225(1), 151-159.