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From molecules… to behavior

2013_06_06_souriscity_0026rDopamine (DA) projections from the midbrain (including ventral tegmental area and substantia nigra) to striatum and frontal cortex play a major role in behavioral actions controlled by reward and in the formation of habits. The dopaminergic system is also involved in drug addiction. Using a combination of behavioral analysis, in vivo and in vitro electrophysiological recordings, genetic tools and optogenetics, we analyze the modifications of DA network dynamics in the different steps leading to nicotine addiction, including genetic and environmental factors, and the consequences of these modifications on decision making.

Latest news

05/10/2017 New article in the Journal of Neuroscience

Doly S., Quentin E., Eddine R., Tolu S., Fernandez S.P., Bertran-Gonzalez J., Valjent E., Belmer A., Viñals X., Callebert J., Faure P., Meye F.J., Hervé D., Robledo P., Mameli M., Launay J.-M., Maldonado R., Maroteaux L.
Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses.
J Neurosci. 2017 Sep 21. pii: 1354-17. doi: 10.1523/JNEUROSCI.1354-17.2017 [Abstract].

02/10/2017 Romain Durand-de Cuttoli danses his PhD

Romain Durand-de Cuttoli, PhD in the team, participates to “Danse your PhD”, a contest organized by Science.

If you want to support Romain, please click on the thumbs up!

27/09/2017 Fabio Marti on TV (TéléMatin – France 2)

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19/09/2017 New article in the British journal of Pharmacological

Mourot A., Herold C., Kienzler M.A., Kramer R.H.
Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.
Br J Pharmacol. 2017 [Abstract].

19/09/2017 New article in Frontiers in Aging Neuroscience

Takillah S. , Naudé J., Didienne S., Decros B., Schenker E., Spedding M., Sebban C., Mourot A., Mariani J. and Faure P.
Acute Stress affects the expression of hippocampal Mu oscillations in an age-dependent manner.
Front. Aging Neurosci. 2017 [Article].

15/09/2017 Congratulations to Nicolas, our IgNobel prize winner, for his work on stinky cheese!!!!!!!!!!!

MEDICINE PRIZE [FRANCE, UK] — Jean-Pierre Royet, David Meunier, Nicolas Torquet, Anne-Marie Mouly and Tao Jiang, for using advanced brain-scanning technology to measure the extent to which some people are disgusted by cheese.

 

REFERENCE: “The Neural Bases of Disgust for Cheese: An fMRI Study,” Jean-Pierre Royet, David Meunier, Nicolas Torquet, Anne-Marie Mouly and Tao Jiang, Frontiers in Human Neuroscience, vol. 10, October 2016, article 511.

New article in Molecular Psychiatry

Morel C., Fernandez S. P., Pantouli F., Meye F. J., Marti F., Tolu S., Parnaudeau S., Marie H., Tronche F., Maskos U., Moretti M., Gotti C., Han M.-H., Bailey, Mameli A. M., Barik J. and Faure P.
Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity.
Molecular Psychiatry 2017 [Article].

New article in Molecular Psychiatry

Benamer N., Marti F., Lujan R., Hepp R., Aubier T. G., Dupin A. A. M., Frébourg G., Pons S., Maskos U., Faure P., Hay Y. A., Lambolez B. and Tricoire L.
GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.
Molecular Psychiatry 2017 [Article].

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New article in Scientific Report

Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, and Philippe Faure.
Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors.
Scientific Report 2017 [Article].