From molecules… to behavior
Dopamine (DA) projections from the midbrain (including ventral tegmental area and substantia nigra) to striatum and frontal cortex play a major role in behavioral actions controlled by reward and in the formation of habits. The dopaminergic system is also involved in drug addiction. Using a combination of behavioral analysis, in vivo and in vitro electrophysiological recordings, genetic tools and optogenetics, we analyze the modifications of DA network dynamics in the different steps leading to nicotine addiction, including genetic and environmental factors, and the consequences of these modifications on decision making.
12/08/2019 New review in Trends in Pharmacological Sciences:
Sarah Mondoloni, Romain Durand-de Cuttoli and Alexandre Mourot
Cell-Specific Neuropharmacology. 2019 DOI: 10.1016/j.tips.2019.07.007 [DOI].
11/07/2019 New review in Nature Reviews Neuroscience:
Pierre Paoletti, Graham C. R. Ellis-Davies and Alexandre Mourot
Optical control of neuronal ion channels and receptors. NatRevNeuro. 2019 DOI: 10.1038/s41583-019-0197-2 [DOI].
13/02/2019 Philippe Faure and Nicolas Torquet were awarded with the La Recherche 2019 price in neuroscience for their work on individuation
Our results, published in August 2018, show that the social environment of mice was a determining factor of their behavioral traits.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d’Izarny-Gargas, Stéphanie Pons,Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot
Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors. elife. 2018 DOI: 10.7554/eLife.37487 [Abstract].
Torquet N., Marti F., Campart C., Tolu S., Nguyen C., Oberto V., Benallaoua M., Naudé J., Didienne S., Debray N., Jezequel S., Le Gouestre L., Hannesse B., Mariani J., Mourot A., Faure P.
Social interactions impact on the dopaminergic system and drive individuality. Nature Communications. 2018 Jul. doi: 10.1038/s41467-018-05526-5. [Abstract].